A Bioinformatics Approach to Mine the Microbial Proteomic Profile of COVID-19 Mass Spectrometry Data

Mass spectrometry (MS) is one of the key technologies used in proteomics. The majority studies carried out using proteomics have focused on identifying proteins biological samples such as human plasma to pin down prognostic or diagnostic biomarkers associated with particular conditions diseases. This study aims quantify microbial (viral and bacterial) healthy plasma. MS data were searched against complete proteomes all available viruses bacteria. With this baseline established, same strategy was applied characterize metaproteomic profile different SARS-CoV-2 disease stages patients. Two detected a high confidence could serve early markers infection. bacterial viral protein content compared for stages. number found increase significantly progression infection, at expense proteins. can be extended aid development tests other infectious diseases based presence samples.